Source: Electric Vehicle News Every Eighth Car Sold In San Francisco Bay Area Is A Plug-In The biggest player in the plug-in segment is, of course, Tesla and its Model 3. With 70,338 Tesla sales (including 51,293 Model 3), the California company absolutely dominates its home market taking 44% from 157,659 plug-in car sales and 74% BEV sales.The Model 3 leads the Near Luxury category by a wide margin, while Model X is second in the Luxury Mid Size SUV category. Chevrolet Bolt EV and Model S took 3rd (respectively) in Subcompact and Luxury and High-End Sports Cars categories.Hat Tip To Emc2!!!Source: California Auto Outlook – 2018 – California New Car Dealers Association US Plug-In Electric Car Sales Charted: December 2018 California’s EV Sales Surge Pushed By Tesla Model 3 Plug-in electric cars outsold hybrids almost 2:1 in CaliforniaAccording to the California New Car Dealers Association’s latest report on the car market in California in 2018, electrification of the state’s fleet accelerated.In the past year, some 2 million new cars were registered in the state (down 2.2% year-over-year), while the passenger car category decreased by 10%, below 900,000.In such circumstances, all-electric cars (mostly passenger cars) increased volume to 94,813 and share to 4.7% (from 2.6% year earlier), while plug-in hybrids grew to 62,846 and 3.1%. In total, plug-in car sales stand 157,659 and at 7.8% of overall volume!Interestingly, BEVs alone outsold conventional hybrids, which noted just 4.1% share (down from 4.6% year ago). According to CNCDA, hybrid sales and market share decreased every year in the past five years, which raises the question of whether or not Toyota noticed this trend?See Also Author Liberty Access TechnologiesPosted on February 21, 2019Categories Electric Vehicle News
As one who closely follows news related to the Foreign Corrupt Practices Act, I was surprised over the past few days about the amount of coverage given to a purported exchange between President Trump and Secretary of State Rex Tillerson about the FCPA.The originating source for this coverage was a relatively minor blurb in this New Yorker article. What surprised me (and you certainly would not know this from reading the New Yorker article because it doesn’t mention this) is that the purported exchange was widely reported back in March.This post highlights how this is an “old news” item, provides facts about FCPA enforcement during the first 8 months of the Trump administration, and demonstrates that President Trump is far from the only politician to raise concerns about the FCPA and its enforcement. Indeed, Democrats and Republicans have long done the same thing.The minor blurb in the New Yorker article was as follows:“In February, a few weeks after Tillerson was confirmed by the Senate, he visited the Oval Office to introduce the President to a potential deputy, but Trump had something else on his mind. He began fulminating about federal laws that prohibit American businesses from bribing officials overseas; the businesses, he said, were being unfairly penalized.Tillerson disagreed. When he was an executive with Exxon, he told Trump, he once met with senior officials in Yemen to discuss a deal. At the meeting, Yemen’s oil minister handed him his business card. On the back was written an account number at a Swiss bank. “Five million dollars,” the minister told him.“I don’t do that,” Tillerson said. “Exxon doesn’t do that.” If the Yemenis wanted Exxon on the deal, he said, they’d have to play straight. A month later, the Yemenis assented. “Tillerson told Trump that America didn’t need to pay bribes—that we could bring the world up to our own standards,” a source with knowledge of the exchange told me.”You would not know it from reading the New Yorker article, but in substance this is what was reported back in March by the Washington Post. This March 9, 2017 article states:“An example of the role Tillerson could play is an exchange in February about the Foreign Corrupt Practices Act. During a White House meeting, Trump complained that the anti-bribery statute cost the United States billions of dollars in lost sales overseas and millions of jobs. According to one insider, Tillerson dissented and described how he had walked away from an oil deal in the Middle East after a leader there demanded a payoff — but later was invited back.” “You’re Exxon!” Trump countered, but the former chief executive dissented again. “No, people want to do business with America.” This pushback from an experienced person is what Trump needs …”.The purported Trump / Tillerson FCPA exchange reported in March 2017 was also picked up by several other sources (see here) including this law firm FCPA client.Predictably, on social media the past few days a conga line of supposed compliance and ethics gurus pounced on the recent New Yorker article, but it appears that the only actual ethical breach is the New Yorker article does not mention that the substance of the purported Tillerson / Trump FCPA exchange was widely reported months before its article.In any event, it seems that much of what passes for “journalism” these days is journalists reporting on what others journalists are writing about and thus, not surprisingly, the FCPA blurb in the New Yorker article quickly spread. (See here and here among other links). The articles use “click-bait” headlines to drive a narrative, yet provide little context for how the narrative is actually false. You would think that a journalist writing an article inferring that President Trump wants to ditch the FCPA would spend an extra few minutes before hitting the publish button to actually learn about FCPA enforcement in the Trump administration.Here are some facts.In the first 8 months of the Trump administration there have been more DOJ corporate FCPA enforcement actions than certain prior years in the Obama administration. In the first 8 months of the Trump administration there have been 5 corporate FCPA enforcement actions with over $535 million in aggregate FCPA settlement amounts. This aggregate settlement amount exceeds aggregate FCPA settlement amounts secured during three years of the Obama administration: 2015, 2012, and 2011 (see here for more information). True, the bulk of this approximate $535 million amount comes from one enforcement action, but this dynamic has always been present in FCPA enforcement statistics regardless of administration.In seeming efforts to ignore or dismiss facts concerning FCPA enforcement in the Trump administration, I have already seen on social media – and predict this will continue – some discounting FCPA enforcement thus far during the Trump administration because the enforcement actions originated in a prior administration. This is true, but again this dynamic has always been part of FCPA enforcement and FCPA enforcement actions during the first few years of the Obama administration originated during a prior administration.Regarding FCPA enforcement during the Trump administration, the fourth quarter of each year has traditionally been an active quarter for FCPA enforcement. In short, FCPA enforcement in the Trump administration appears to be following a normal path as predicted in this post. Some additional context.The notion that Trump purportedly expressed concern about how FCPA enforcement impacts U.S. business hardly makes him unique as politicians (both Democrats and Republications) have articulated similar concerns since the FCPA was enacted in 1977.For instance, in 1980, the Carter administration (recall that President Carter signed the FCPA into law in 1977) sent a report to Congress prepared by the Secretary of Commerce and the U.S. Trade Representative titled “Report of the President on Export Promotion Functions and Potential Export Disincentives.” In pertinent part, the report stated:“The [FCPA] is identified by businessmen and attorneys as one of the most significant export disincentives. […] The Act inhibits exporting because of uncertainty within the business community about the meaning and application of some of its key provisions.“Uncertainty about the meaning of key provisions of the FCPA and how it will be applied is having a negative effect on U.S. exports. Many of the businessmen and attorneys consulted expressed the view that this uncertainty has a far greater impact than the actual prohibition against bribery. The problem described, in essence, is that what conduct is prohibited and what conduct is not prohibited under the Act is often unclear. In order to avoid possible violations of the Act, attorneys often give such cautious guidance that their clients simply forego any transactions where the FCPA could possibly become an issue.”“The effects of these uncertainties reportedly manifest themselves in various ways. Consultations with the private sector revealed instances in which U.S. companies:withdrew from joint ventures for fear they later could be held responsible for the acts of their foreign partners; incurred substantial legal and investigative costs to check the backgrounds of their sales agents abroad; were unable to obtain the services of effective sales agents; lost contracts simply because of the time needed to investigate sales agents abroad and institute safeguards; withdrew from existing markets; and declined to enter new markets.”“Finally, companies point out that the extent to which companies have been successfully prosecuted under the FCPA does not define the extent of the disincentive. Uncertainty can be a disincentive without any prosecutions and, moreover, exports are inhibited merely by the possibility of public charges and the adverse publicity surrounding them. Even where a company is totally convinced that a court would find that it had not violated the FCPA, it nonetheless may forego the export opportunity for fear that an enforcement agency could publicly charge it with a violation of the Act.”In 1981, the Government Accounting Office (“GAO”), the investigative arm of Congress, released a report titled “Impact of Foreign Corrupt Practices Act on U.S. Business.” The report was based in part on a GAO questionnaire survey of 250 companies randomly selected from the Fortune 1000 list of the largest industrial firms in the U.S. and the questionnaire addressed the FCPA’s relationship to the following four areas: (1) corporate policies and/or codes of conduct; (2) corporate systems of accountability; (3) cost burdens, if any, incurred by management to comply with the FCPA; and (4) corporate opinions regarding the: (i) FCPA’s effect on U.S. corporate foreign sales; (ii) the clarity of the FCPA’s provisions; (iii) the potential effectiveness of an international anti-bribery agreement; and (iv) perceived effectiveness of the FCPA in reducing questionable payments.The GAO found that while the FCPA “has brought about efforts to strengthen corporate codes of conduct and systems of internal accounting control,” corporations reported that “their efforts to comply with the [the FCPA] have resulted in costs that were greater than the benefits received” and that a substantial number of businesses “reported that they had lost oversees business as a result” of the FCPA. The GAO report noted concerns that the FCPA’s anti-bribery provisions were “vague and ambiguous” and stated that while “unambiguous requirements may be impractical and could provide a roadmap for corporate bribery” companies operating in the global marketplace “should be subject to clear and consistent demands by the Government agencies for enforcing the act.”As noted in this previous post, President Reagan’s administration sought decriminalization of foreign payments subject to the FCPA.Fast forward to the FCPA’s modern era and some of the most forceful critiques of the FCPA during the Senate’s 2010 FCPA hearing came from Democratic Senators. For instance, Senator Amy Klobuchar (D-MN) directed the following comment to the DOJ representative at the hearing:“[O]ne of the basic principles of due process is that people in companies have to be able to know what the law is in order to comply with it. And I will tell you that I have heard from many very good standing companies in my State that they do not always know what behavior will trigger an enforcement action.”Likewise at the hearing Senator Christopher Coons (D-DE) directed the following statement to the DOJ representative at the hearing:“Has there been any reported appreciable change in the conduct or behavior of public officials overseas in response to our more aggressive enforcement or, as some companies have suggested, is this simply putting U.S.-headquartered companies at a disadvantage in not actually having some positive or desirable impact on the conduct of foreign officials?” Learn More & Register FCPA Institute – Boston (Oct. 3-4) A unique two-day learning experience ideal for a diverse group of professionals seeking to elevate their FCPA knowledge and practical skills through active learning. Learn more, spend less. CLE credit is available.
McAtee is the father of AT&T general counsel David McAtee II and has defended “Big Four” accounting firms, developed programs for antitrust compliance and represented clients in matters involving the Department of Justice, the Federal Trade Commission and antitrust divisions of state attorneys general offices . . .You must be a subscriber to The Texas Lawbook to access this content. Not a subscriber? Sign up for The Texas Lawbook. Remember me Password Lost your password? Username
Tweet6Share66ShareEmail72 Shares“Will everyone please take out your cell phones and…. turn them ON!” Implores Dr. Bill Thomas at the start of all of his ChangingAging Tour performances. Social change and personal growth move at the speed of relationships, for better or worse we are connected most often through our smart phones.For the 2017 ChangingAging Tour, we are taking a page from grassroots movements to break down boundaries and inspire genuine multi-generational engagement. We are now organizing a series of webinars with partners in our 2017 tour cities to introduce specific approaches that have the most potential to support age inclusive community building. Click here to RSVP for our next webinar March 9One technique we will introduce is based on a Liberating Structure called “Social Network Webbing.” This simple exercise any group can use to visually map their informal relationship connections and decide how to take action around a collective purpose. By shifting away from top-down control individuals are encouraged to take action by showing them the power of their personal connections. These loose connections — even friends of friends — can be engaged in a way that has a powerful influence on progress without complex strategies or big investments in planning. In this digital age of Facebook and Twitter, we emphasize the size of our networks or number of followers, often neglecting the actual human interactions so important to nurturing our relationships. I recently introduced this exercise to Age Friendly Seattle as a way to begin expanding the coalition to include representatives under the “eight age friendly domains of livability.” The outcome was an amazing visual representation of our collective network. It clearly highlighted members of our group who are connected to influential people that could help us advance age friendly community goals. A Liberating Structures workshop doing Social Network Webbing.Tapping into our relationships is especially important in building a movement such as ours because ageism spans all sectors of society. We have to engage not only aging-specific industries such as long term health care, but also education, the arts, and private and public institutions. Hidden within each of our social networks are these powerful connections that can truly Change Aging. Take the first steps in unlocking your resources; sign up for regular updates from ChangingAging.org, click here to request an invitation to attend our next webinar on March 9 and get tickets to a tour performance nearest you! Related PostsWe Need an Age Friendly RevolutionA powerful way to counter divisive rhetoric and demagoguery coming out of Washington, D.C., is to do something unexpected — start an Age Friendly city revolution.Grateful Changemakers: ChangingAgingAll of ChangingAging’s performances, all of our advocacy, all of our innovation is driven at its core by love. Love is the driving force behind combating ageism.Who Will Take Up the Baton?In preparing to hit the road this April for the 2017 ChangingAging Tour, my eye increasingly falls on that next generation to take up the purpose of Changing Aging.Tweet6Share66ShareEmail72 SharesTags: grassroots Liberating Structures
by, David Goff, ChangingAging ContributorTweetShare11ShareEmail11 SharesI’ve been dwelling with this question for a while. Like any good, real, question it is taking me for a ride. What makes a difference?Before I get into my response to this compelling question, I just want to extoll the value of a good question. A really good question, such as this one, doesn’t have one right answer, and doesn’t lend itself to simplicity. In addition to asking one to reflect on a specific something, it asks one to let in the complex, incredible diversity of this world. That is what I hope to do, as I let this question lead me deeper and deeper into mystery.My response to this question has been one that has unfolded. The question is still resonating within me. It is still provoking my awareness. Level-by-level I am discovering that I have very little reason to believe that I have any kind of response that makes the question go away. I am being skewered (changing one could say, the question itself is making a difference) by the uncertainty it is raising in me.Initially, I thought this was a fairly easy question for me to address. I have been vocal and consistent advocate for community. On some level I know I believe that caring and real connection make a big difference. I have spent a good part of my life trying to restore the natural social habitat of our species. I really believe that our social nature, which runs wild in our feelings, is an endangered life form. I have spent, and probably will spend, the bulk of my life-energy working on behalf of this perception. I could compellingly argue about the importance of this issue. I have good reason to believe that community has big implications for our complex consciousness, our sense of belonging, and our future.Therefore, you can imagine my surprise, when this question led me to a deeper more fundamental and miraculous realization. It was a week after I thought I laid the question to rest. I was satisfied with what I believed, and my efforts toward that end. Suddenly, I became aware that it wasn’t given to me, as a human being, to know what made a difference. I really didn’t know what made a difference. This was devastation to the part of me that was invested in community (in my own knowing). Miraculously, even with the loss of my precious illusion (and I could feel it/me dissolving), I experienced joy and awe.“Not knowing” freed me. In ways I am still discovering. I’ve been pleasantly surprised by the miraculousness of not knowing what makes a difference. Where I think I might feel bereft, I am discovering the warm pleasure of coming to my limitations. The fundamental paradox that everything makes a difference and nothing makes a difference places me in a wonderful position. I can’t not try, nor can I necessarily make a difference. Instead of being disheartened by my own ineffectuality, I am instead graced to know that I alone am not responsible for change.All I can do is “show up.” That alone is not enough. Something more happens, if change occurs, it is something I can’t make happen. My presence, and the energy I put into making a difference, add up to increased probability, but they are not decisive.Or, things might change for reasons I cannot fathom. I don’t even get to be aware of all of it, there is no intention on my part. What makes a difference then? There must be some other kind of ripeness to change. Things happen, I don’t know why. Maybe I am an ingredient of that change, but I am completely oblivious of it. I make a difference (or, do I?) without knowledge or effort. I don’t notice, or know. Shit happens.I like arriving at this realization. It lets some of me off the hook (of responsibility) and strangely puts other parts of me more firmly on the hook. What do I mean? I am not sure yet. Play with this question a while and see what it does for you. For me, it relieves me of thinking I am that important. Apparently, I’m not. At the same time I am sometimes.This floors me. I don’t get to know when I matter. Thus, I want to show up for everything — I might be a necessary ingredient.“Not knowing” seems to make me a more effective advocate for making a difference.I’m savvy enough to know that when I think I know, I probably don’t. Now, thanks to this question, I am learning that ‘not knowing’ is probably the best way to advocate for change. What is ripe for real change is most likely beyond me, and my efforts. Change, therefore, is safe from me, and more likely to be change for change’s sake. Then, how I respond is how I aid change.Making a difference is, and is not, up to me. Instead of that disappointing news discouraging me, I feel freed, and less distorted by my own shortcomings. Change happens, Lord knows how or why. I want to believe it can be directed. That some law of the Universe applies. Knowing that making a difference is to some extent my doing, and knowing that it is not, somehow ties me more firmly into the mystery of it all.Photo by Evan Dennis on UnsplashRelated Posts#AskDrBill How to Play Life’s Most Dangerous GameBeginning March 2016, we will launch a new podcast #AskDrBill How to Play Life’s Most Dangerous Game featuring in-depth discussion of and answers to some of the most penetrating and provocative questions YOU ask us.The Biggest Questions in Palliative Care and Geriatrics Finally AnsweredEvery week we have been posting a lot of questions on GeriPal about some of the biggest issues in geriatrics and palliative care. These range from how to define our professions (both in geriatrics and palliative care), how to communicate with pat…Live Elder Commentary Tonight During Second Presidential DebateEVENING UPDATE: I am moderating a discussion with several other elders during the presidential debate tonight. To watch the ABC News/Yahoo! News Elders Response Hangout live at YouTube or to view the archived video later when you have time later,…TweetShare11ShareEmail11 SharesTags: Change Slow Lane
Source:http://www.oncotarget.com/news/pr/pd-l1-expression-in-medulloblastoma-an-evaluation-by-subgroup May 3 2018This study evaluated the expression of PD-L1 and markers of immune mediated resistance in human medulloblastoma, the most common malignant pediatric brain tumor.In cell lines, SHH MB, which are low-MYC expressing, demonstrated both constitutive and inducible expression of PD-L1 while those in Group 3/4 that expressed high levels of MYC had only inducible expression.MB expresses low levels of PD-L1 facilitating immune escape.”Tumors in the SHH subgroup are characterized by genetic alterations activating this key developmental pathway. WNT subgroup tumors have alterations in the wingless/ -catenin developmental pathway.”Related StoriesImmunotherapy increases five-year survival rate of patients with advanced non-small cell lung cancerLow-dose radiation therapy may increase uptake of therapeutic nanoparticles by brain tumorsNanoparticles used to deliver CRISPR gene editing tools into the cellMost patients are assessed for PD-L1 expression prior to starting therapy, but the expression of PD-L1 during the entire course of treatment remains unclear, as does the relationship between changing PD-L1 expression and therapeutic responses.In support of PD-L1 pathway activity in human MB, the researchers demonstrated that MB cell lines robustly up-regulated PD-L1 when they simulated an anti-tumor immune response in vitro by exposing the cell lines to recombinant human IFN-.In further support of the notion that MB adaptively up-regulates PD-L1 as a specific response to immune mediated stimulation is the finding that radiation induced PD-L1 expression but not to the extent generated by IFN-.The finding that both IFN- and radiation induced PD-L1 expression in vitro and the paucity of PD-L1 expression in vivo in the absence of TIL further emphasizes the concept that immune adjuvants will likely be needed to fully realize the benefit of PD-1 blockade in cold tumors such as MB.Expression of MHC II by MB is unusual as this molecule is usually a feature of dendritic cells and other APCs indicating that this tumor may be directly inhibiting anti-tumor immune responses by masquerading as an inhibitory APC MHC II expression may also indicate a role for the immune checkpoint molecule, lymphocyte activating gene-3 in MB whose primary ligand is MHC II.
According to study leader Nathan Hawkshaw, of the University of Manchester in England, this new drug has never been considered in the treatment of baldness. It has been seen that the this could promote human hair growth. He said this could make a difference to people suffering from hair loss one day. To become a reality however, the drug would need to pass through clinical trials that would show it is effective in re-growing hair and also safe for use.The researchers explain that at present there are only two drugs – Minoxidil and Finasterite that can help temporarily and relatively unsuccessfully in male pattern of baldness. These drugs are however fraught with side effects and are not always successful. While minoxidil can be used for both men and women, finasteride is useful only in men.Hawkshaw and his colleagues thus went ahead to explore the drug WAY-316606 that was originally developed to stop bone loss seen in osteoporosis. The drug is shown to inhibit the production of a protein called SFRP1. This protein is responsible for hair loss and inhibits growths of several other tissues by blocking a WNT molecular pathway. When used on hair follicles thus, WAY-316606 showed benefits and hair regrowth.Related StoriesTop four things seniors need to know to have a safe and healthy summerStudy reveals dual effects of new osteoporosis therapy on bone tissueLong-term follow-up of childhood cancer survivors is essential to maintain bone healthThe researchers used samples from the lab containing scalp hair follicles from over 40 male hair-transplant patients and were pleased to report encouraging results with the test drug.Baldness or pathological hair loss One of the most common forms of hair loss is male pattern baldness. It affects around 50% of men by time they reach the age of 50. It is usually hereditary and thought to be associated with having an excess of a certain hormones, which has an effect on hair follicles. The hair loss usually begins while a man is in his late 20s or early 30s. Female pattern baldness most commonly affects post-menopausal women, possibly as a result of hormonal changes. Alopecia areata commonly manifests as patchy baldness that may resolve and then recur. It can affect both men and women at any age. It is caused by an immune system disorder and people with autoimmune conditions are more likely to be affected. In one fifth of cases, alopecia areata is hereditary. Alopecia or baldness can also be due to scars or cicatricial alopecia. The hair follicles are completely destroyed and hair does not grow again. The condition affects both males and females and is more common among adults than children.Reference: http://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.2003705 Image Credit: MRAORAOR / Shutterstock By Dr. Ananya Mandal, MDMay 9 2018According to researchers, a drug used to treat patients with osteoporosis may soon be helpful in treating baldness. The study was published in the latest issue of the journal PLOS Biology this week.
AnonShop Eassybuyonline Instabill ECS-Rx Medstore.biz One Stop Pharma RemedyMart RxCash.Biz TramadolHub XLPharmacy Source:https://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm609869.htm Jun 6 2018The U.S. Food and Drug Administration today announced that it has warned nine online networks, operating a total of 53 websites, that they must stop illegally marketing potentially dangerous, unapproved and misbranded versions of opioid medications, including tramadol and oxycodone.Companies who fail to correct the violations, as outlined in the warning letters, may be subject to enforcement action, including product seizure or injunction.”The FDA is taking additional steps to protect U.S. consumers from illicit opioids by targeting the websites that illegally market them and other illicit drugs. The internet is virtually awash in illegal narcotics and we’re going to be taking new steps to work with legitimate internet firms to voluntarily crack down on these sales. As part of that effort, we’re hosting a summit with internet stakeholders to find new ways to work collaboratively with them to address these issues. At the same time, we’ll be taking action against firms whose websites deliberately break the law,” said FDA Commissioner Scott Gottlieb, M.D. “This illegal online marketing of unapproved opioids is contributing to the nation’s opioid crisis. Today’s warning letters go right to the source of this illegal activity to let online network operators know that marketing illegal and unapproved opioids directly to U.S. consumers will not go unchallenged by the FDA. Opioids bought online may be counterfeit and could contain other dangerous substances. Consumers who use these products take significant risk with their lives. The new warning letters are part of a comprehensive campaign to target illegal sales of unapproved opioids. We’ll be following these actions with additional steps in coming months to crack down on the flow of illegal, unapproved opioids sold online and shipped through the mail.”Patients who buy prescription medicines from illegal online pharmacies may be putting their health at risk because the products, while being marketed as authentic, may be counterfeit, contaminated, expired, or otherwise unsafe. As noted in the warning letters, these websites offer for sale opioids that are misbranded and unapproved new drugs, including unapproved tramadol and oxycodone, in violation of the Federal Food, Drug, and Cosmetic Act.This is particularly concerning considering that FDA-approved tramadol and oxycodone carry boxed warnings, which is the FDA’s most prominent warning, indicating that the drugs carry a significant risk of serious or even life-threatening adverse effects. The boxed warnings address risks including addiction, abuse, misuse, life-threatening respiratory depression (breathing problems) and neonatal opioid withdrawal syndrome (withdrawal symptoms in newborn babies). In addition, when taken with other central nervous system depressants, including alcohol, their use may result in coma or death.The networks receiving warning letters include: Related StoriesUS dentists write more opioid prescriptions than England dentistsStudy: Dozens of counties in the U.S. are at highest risk for opioid deathsParental opioid use doubles the risk of suicide attempts by their children”The public needs to know that no one is authorized to sell or distribute opioids via the internet in the U.S., with or without a prescription,” said Donald D. Ashley, director of the Office of Compliance in the FDA’s Center for Drug Evaluation and Research. “Drug dealers and rogue website operators are using the internet to fuel the opioid crisis, heartlessly targeting millions of Americans struggling with opioid use disorder. We will continue to aggressively pursue these criminals and take swift action to protect the American public.”The FDA requested responses from each of the companies within 10 working days. The companies are directed to inform the agency of the specific actions taken to address the agency’s concerns.Opioid addiction is an immense public health crisis. Addressing it is one of the FDA’s highest priorities and supports the U.S. Department of Health and Human Services’ 5-Point Strategy To Combat the Opioid Crisis. One critical step to addressing this public health emergency is the adoption of a more proactive approach by internet stakeholders to crack down on internet traffic in illicit drugs. Illegal online pharmacies, drug dealers and others are increasingly using the internet to further their illicit distribution of opioids, where their risk of detection and repercussions is significantly reduced.As part of this effort, Commissioner Gottlieb has invited internet stakeholders and thought-leaders, government entities, academic researchers and advocacy groups to an Online Opioid Summit on June 27 to discuss ways to collaboratively take stronger action in combatting the opioid crisis by reducing the availability of illicit opioids online. Topics to be addressed during the Summit include: research into the ease with which illicit opioids can be purchased online and industry approaches to addressing opioids marketed online, followed by a roundtable discussion to identify gaps and new solutions.In addition to health risks, illegal online pharmacies can pose other risks to consumers, including credit card fraud, identity theft, and computer viruses. The FDA encourages consumers to report suspected criminal activity to the FDA’s Office of Criminal Investigation. The FDA also provides consumers with information to identify an illegal online pharmacy and information on how to buy medicine safely online through BeSafeRx: Know Your Online Pharmacy.The FDA remains committed to addressing the national crisis of opioid addiction on all fronts, with a significant focus on decreasing exposure to opioids and preventing new addiction; supporting the treatment of those with opioid use disorder; fostering the development of novel pain treatment therapies and opioids more resistant to abuse and misuse; and taking action against those who contribute to the illegal importation and sale of opioids. The agency will also continue to evaluate how opioids currently on the market are used, in both medical and illicit settings, and take regulatory action where needed.
Source:https://www.acs.org/content/acs/en/pressroom/presspacs/2018/acs-presspac-july-11-2018/crisprs-growing-pains.html Jul 12 2018In the six years since its inception, CRISPR gene editing has experienced ups and downs, from giddy excitement over the technology’s potential to cure genetic diseases to patent disputes, ethical considerations and cancer scares. Despite recent setbacks, companies developing CRISPR therapies are forging ahead, reports an article in Chemical & Engineering News (C&EN), the weekly news magazine of the American Chemical Society.Related StoriesResearchers develop a more precise version of CRISPR-Cas9 gene-editing systemIDT releases new ultra-high performance CRISPR Cas12a enzymeDiscovery of small-molecule inhibitors could enable precise control over CRISPR-Cas9 genome editingThe CRISPR process makes double-stranded breaks at particular sites in DNA, specified by a guide RNA, with an enzyme called Cas9. The cell machinery then repairs the DNA break, while a CRISPR template DNA sequence introduces edits to restore a defective gene’s function. The first clinical trials of CRISPR will take place within the next year. However, since May 2017, a few studies in mice and human cell lines have raised safety concerns over the technology, writes Assistant Editor Ryan Cross.Last month, a pair of papers in Nature Medicine indicated that CRISPR doesn’t work in two human cell lines unless a protein called p53 is broken or missing. Because cancer cells often have defective p53, some media coverage linked CRISPR to cancer. However, representatives from companies developing the technology downplay these results because they are not using these cell lines for their therapies. They also note that an earlier report suggesting that CRISPR is not as precise as intended has been retracted because the alleged off-target effects of the technology were later attributed to natural genetic variation in the studied mice.
Inspired by a 4000-year-old painting, physicists have figured out how ancient Egyptians may have dragged heavy statues across the desert. The image (above), found in an ancient tomb at Dayr al-Barsha, about 320 kilometers south of Cairo, depicts 172 workers dragging a colossal statue of Djehutihotep, a provincial ruler, on a wooden sled, while one worker pours what could be water in front of the procession. Although previous experiments suggested that adding water to sand would increase rather than decrease friction, a team of scientists wondered whether just the right amount of water could help bond grains of sand together, making the sand more rigid and reducing friction. To find out, the researchers measured the force it took to drag a sandpaper-bottomed sled carrying a 2-kilogram weight across a slightly damp bed of sand. Increasing the sand’s water content to 5% cut friction by as much as half, depending on the kind of sand the team tested. Beyond 5%, however, the water-sand mix lost its stiffness again. The results, reported in Physical Review Letters, could help manufacturers transport materials such as drink mixes or powders used in pharmaceuticals more efficiently, shaving a bit off the industry’s enormous carbon footprint. Another bit of ancient Egyptian wisdom revealed, thanks to modern science.See more ScienceShots.
Kidnapped, drugged, and left abandoned in a field, bees can still find their way home using mental maps of their surroundings, according to a new study that could pose a major challenge to current thinking about human memory and cognition. Curious to know more about the insects’ navigational abilities, a team of biologists and psychologists fit 57 bees with radio transponders to track their paths and then trained them to find a feeder 300 meters from their hive. Once the insects knew the route, the researchers captured the bees and placed about half of them into a dark box for 6 hours. They anesthetized the others, disrupting their sense of time and, as a result, their ability to use the sun’s position in the sky to navigate. After a 6-hour delay and a move to a new location 600 meters from the hive, the experimenters released their captives. The paths that the drugged and undrugged groups took at first differed, reflecting the foggy bees’ skewed sense of time (imagine waking at sunset thinking it was sunrise and trying to find north), but the drugged bees soon corrected. Both groups ended up on similar paths, returned to the hive about the same time, and returned in similar numbers: Twenty-nine of 36 drugged bees and 18 of 21 sober bees made it back to the hive. That means the insects weren’t relying solely on the sun to navigate and instead must be using mental maps, the team reports online today in the Proceedings of the National Academy of Sciences. Bees don’t have the brain structure, called the hippocampus, thought to store the spatial memories underlying mental maps in humans. So psychologists may have to rethink how we ourselves navigate, even when we’re not drugged and kidnapped on the way home.*Correction, 3 June, 4:58 p.m.: The photo above has been replaced; the previous photo depicted a hover fly, not a bee.
Venezuela has its first dinosaur! The 200-million-year-old creature, pictured here in an artist’s reconstruction, has been named Laquintasaura venezuelae, after the La Quinta Formation of the Venezuelan Andes mountains in which it was found. It was the size of a small dog and most likely a plant eater, but the curved tips of some of its teeth suggest it might also have chomped on insects. The research team, which reports the discovery online today in the Proceedings of the Royal Society B, says that the new dino is important for several reasons. First, it is an early ornithischian dinosaur, a group that includes later horned critters such as Triceratops and Stegosaurus, and which split from the saurischian dinosaurs (which include behemoths as diverse as the long-necked Diplodocus and the meat-eating Tyrannosaurus rex) soon after dinosaurs arose about 230 million years ago. Very few early ornithischians are known, so the new Venezuelan species may provide important clues about early dino evolution. Second, the sighting of an early, well-dated ornithischian so near the equator (which at that time ran right through what is today Venezuela) expands the range of this dino group and contradicts earlier hypotheses that ornithischians could not have lived in such warm, tropical climates. And third, at least four Laquintasaura individuals were found together, which the team interprets as evidence that ornithischian dinos lived in “herds,” a kind of social behavior not previously seen so early in the fossil record.
No matter which side of the dogs versus cats debate you’re on, one thing is for certain: It’s way more fun to watch a dog drink water. Because canines have floppy jowls instead of complete cheeks, they can’t generate suction with their mouths, so instead they’ve evolved the sloshy, lapping strategy everyone is familiar with. Now, using an array of high-speed cameras and mathematical models, physicists have teased out the fluid dynamics behind how dogs drink. As seen in the video above, a dog curls its tongue posteriorly and plunges it through the water’s surface. When the tongue returns, it drags a column of water up into the dog’s mouth, the team reports today at the American Physical Society’s Division of Fluid Dynamics’ annual meeting in San Francisco. The process isn’t as precise as it sounds, as evidenced by the slippery floors of dog owners the world over. Cats actually use a similar lapping strategy, but their tongues never break the water’s surface, which makes for much tidier drinking. That’s not to say cats don’t spill water—they just do it on purpose.For more on man’s best friend, see the Science News team’s latest coverage of doggy science.(Video credit: Sean Gart/Virginia Tech, Jake Socha/Virginia Tech, Pavlos Vlachos/Purdue University, Sunghwan Jung/Virginia Tech, and the APS Division of Fluid Dynamics)
Sasha Obama And Her Prom Date Broke The Internet Cormier has always displayed excellence when it came to academics. Early on she decided that she wanted to enter a program that allowed her to simultaneously earn her high school diploma and a college degree. With the support of her family, she enrolled in Early College Academy which is a part of South Louisiana Community College’s campus. Outside of school, she was very involved in her local community, often mentoring young girls who want to pursue careers in STEM, tutoring youngsters and adults, and volunteering at a nursing home.The journey hasn’t been easy for Cormier. She’s dealt with several immune system issues which have caused many hospital visits. Despite her health ailments, she prevailed. She ended up graduating with a high school diploma and an associate’s degree. Her dedication to her education and making a positive impact in her community caught the attention of higher education institutions across the globe and earned her $8.7 million in scholarships and grants from GE, Burger King and other companies and organizations.Her hospital visits led her to choose a career path in medicine. “Since I was a child, I was always in and out of the hospital,” Cormier told USA Today. “When I was young, it affected my self-esteem. But now I can use it to inspire others.” She said selecting Xavier University of Louisiana was an easy decision because her personal goals are aligned with the school’s values.The aspiring doctor hopes that her journey will inspire others.SEE ALSO:Yale University Elects First Black Student Body President14-Year-Old Sydney Wilson Becomes Youngest Student Accepted Into Spelman Receiving over 100 college acceptance letters can be overwhelming for a high school graduate, but for 18-year-old Normandie Cormier, it was clear that she would begin her next chapter at a historically Black college and university. According to USA Today, after being accepted to 139 colleges through the Common App and the Common Black College App, the Louisiana native has decided to further her education at Xavier University in New Orleans. Most parents and guidance counselors advise high school seniors to apply to more than one college — to have at least one “backup school.”Well, Normandie Cormier of Lafayette had more than 100 backups. https://t.co/JFTxju45Cc— azcentral (@azcentral) May 29, 2019 graduate , Graduation , Louisiana , Normandie Cormier , Xavier University AddThis Sharing ButtonsShare to FacebookFacebookFacebookShare to TwitterTwitterTwitterShare to MoreAddThisMoreShare to EmailEmailEmail
Changes being proposed to formulate new county By L. Parsons Navajo County resident Jesse Valencia has been in conversations with Arizona legislators regarding redrawing of county lines. Valencia, founder of the proposed Sitgreaves County Project, explained, “The idea came from seeing that,Subscribe or log in to read the rest of this content. Bottom Ad December 3, 2018
US mulls increasing merit-based immigration to 57% Related News Advertising Best Of Express Trump and Kim have met twice since Kim entered talks with the United States early last year to deal away his advancing nuclear arsenal in return for political and economic benefits.Their first summit in Singapore in June last year ended with Kim’s promise to work toward complete denuclearization of the Korean Peninsula. But it lacked any specific timetable and roadmap. In Singapore, the two leaders also agreed to improve bilateral relations and build lasting peace on the peninsula.They met again in Vietnam in February, but that second summit collapsed due to disputes over how much sanctions relief North Korea should win in return for dismantling its main nuclear complex _ a limited denuclearization step.Kim has since asked Trump to work out acceptable proposals to salvage the negotiations by the end of this year. U.S. officials said sanctions on North Korea would stay in place until North Korea takes firmer steps toward nuclear disarmament. Donald Trump with Kim Jong Un. (Reuters/File)North Korea said Saturday President Donald Trump’s offer to meet leader Kim Jong Un at the Korean Demilitarized Zone is a “very interesting suggestion,” brightening prospects for a third face-to-face meeting between the two leaders. Taking stock of monsoon rain Post Comment(s) More Explained US House votes to set aside impeachment resolution against Trump Trump says ‘will take a look’ at accusations over Google, China Karnataka trust vote today: Speaker’s call on resignations, says SC, but gives rebel MLAs a shield Choe’s statement was carried via the North’s official Korean Central News Agency.Earlier Saturday, Trump invited Kim to shake hands during his planned visit to the DMZ, which has served as a de-facto border between the Koreas since the end of the 1950-53 Korean War. Trump is scheduled to fly to South Korea later Saturday for a two-day trip after attending the G-20 summit in Osaka, Japan.Trump tweeted that “If Chairman Kim of North Korea sees this, I would meet him at the Border/DMZ just to shake his hand and say Hello(?)!”“All I did is put out a feeler if you’d like to meet,” Trump said later of the invitation, adding that he’s not sure of Kim’s whereabouts. Virat Kohli won’t have a say in choosing new coach After Masood Azhar blacklisting, more isolation for Pakistan Talks of a revival of diplomacy have flared again since Kim and Trump recently exchanged personal letters. Kim called Trump’s letter “excellent” while Trump described Kim’s as “beautiful.”The United States and North Korea are in a technical state of war because the 1950-53 Korean War ended with an armistice, not a peace treaty. About 28,500 American soldiers are deployed in South Korea as deterrence against potential aggression from North Korea. Advertising By AP |Seoul | Updated: June 29, 2019 1:06:16 pm The North’s First Vice Foreign Minister Choe Son Hui said that the meeting, if realized, would serve as “another meaningful occasion in further deepening the personal relations between the two leaders and advancing the bilateral relations.”Explained: Demilitarized Zone, where Trump may meet Kim, is a vestige of Cold WarChoe still said that North Korea hasn’t received an official proposal for the DMZ meeting from the United States. Her comments suggested that North Korea is willing to accept Trump’s idea if it gets a formal U.S. offer for the meeting, according to some observers in Seoul.
Source:https://www.acs.org/content/acs/en/pressroom/presspacs/2018/acs-presspac-september-26-2018/paintable-chemotherapy-shrinks-skin-tumors-in-mice-.html Reviewed by Alina Shrourou, B.Sc. (Editor)Sep 26 2018Skin acts as the first line of defense against pathogens and other harmful material from outside the body. Yet this barrier also excludes some beneficial drugs that could treat skin diseases. Now, researchers have taken the first steps in developing a chemotherapy for melanoma that can be “painted” directly on the skin, rather than injected or taken orally. They report their results in ACS Nano.According to the Skin Cancer Foundation, melanoma is the deadliest form of cancer because of its tendency to spread, or metastasize, from the skin to other parts of the body. Common treatments include surgery, radiation therapy and intravenous chemotherapy, but these can cause pain or unpleasant side effects. If scientists could find a way to administer chemotherapy through the skin, they could target the treatment directly to the tumor site and possibly avoid side effects. Bingfang He, Ran Mo and colleagues wanted to develop a gel that patients themselves could apply to a skin tumor. But first they had to figure out how to get the therapy to penetrate deep within the skin.Related StoriesExercise program improves anxiety, mood in older adults who received chemotherapyNew ‘virtual biopsy’ device developed to detect skin tumorsEmbrace your natural skin tone to prevent skin cancer, say expertsFor this purpose, the researchers assembled nanoparticles called “transfersomes,” which consist of a phospholipid bilayer and surfactants that encapsulate drugs or other molecules — in this case, the chemotherapy drug paclitaxel. The surfactants made the particles more deformable so that they could better infiltrate the skin; these compounds also affected the lipid matrix of the skin to help the particles more easily pass. The researchers added a peptide to the surface of the transfersome to further help the particle penetrate the skin, as well as enter tumor cells. To increase the time that the transfersomes persisted on skin, the researchers embedded the nanoparticles into a hydrogel. Then, they painted the gel on tumors of melanoma-bearing mice once a day, in combination with intravenous administration of paclitaxel every other day. After 12 days, the tumors of these mice were about half the size of tumors in mice treated with intravenous paclitaxel alone, suggesting that the transfersome gel helped slow tumor growth.
Reviewed by James Ives, M.Psych. (Editor)Jan 9 2019Posttraumatic stress disorder (PTSD) was associated with cardiovascular disease and cancer, as well as the metabolic syndrome, in a new study.In the Journal of Neuroscience Research study of 84 individuals diagnosed with PTSD (39 victims of terrorist attacks and 45 victims of other traumatic events), males were more likely to have circulatory and metabolic complications, whereas females had a higher prevalence of benign and malignant cancers.Related StoriesHow cell-free DNA can be targeted to prevent spread of tumorsResearchers use AI to develop early gastric cancer endoscopic diagnosis systemTrends in colonoscopy rates not aligned with increase in early onset colorectal cancerA longer duration of PTSD was associated with the development of cardiovascular disease, while PTSD following terrorist attacks was associated with a higher cancer prevalence.”An explanation of why victims of terrorism may have a higher cancer prevalence than victims of other traumatic events, such as accidents, may be the intentional infliction of harm on the victim causing a more dysregulated stress response. A challenge for the future is monitoring the physical health of victims over time and understanding psychological and neurobiological processes producing this effect,” said co-author Dr. Andrea Pozza, of the Santa Maria alle Scotte University Hospital, in Italy. “Longer untreated PTSD was associated with higher prevalence of cardiovascular disease regardless of the event type: this suggests the importance of early intervention for PTSD and also education programs for the general population to make people aware about PTSD early warning signs and how to recognize them.” Source:https://newsroom.wiley.com/press-release/journal-neuroscience-research/does-ptsd-affect-heart-disease-and-cancer-risk