We present a relative sea-level (RSL) history, constrained by AMS radiocarbon-dated marine–freshwater transitions in isolation basins from a site adjacent to the Lambert Glacier, East Antarctica. The RSL data suggest an initial ice retreat between c. 15,370 and 12,660 cal yr B.P.. Within this period, meltwater pulse IA (mwp IA, between c. 14,600–14,200 and 14,100–13,700 cal yr B.P.) occurred; an exceptionally large ice melting event, inferred from far-field sea-level records. The RSL curve shows a pronounced highstand of approximately 8 m between c. 7570–7270 and 7250–6950 cal yr B.P. that is consistent with the timing of the RSL highstand in the nearby Vestfold Hills. This is followed by a fall in RSL to the present. In contrast to previous findings, the isolation of the lakes in the Larsemann Hills postdates the isolation of lakes with similar sill heights in the Vestfold Hills. An increase in RSL fall during the late Holocene may record a decline in the rate of isostatic uplift in the Larsemann Hills between c. 7250–6950 and 2847–2509 cal yr B.P., that occurred in response to a documented mid-Holocene glacier readvance followed by a late-Holocene retreat.